The Quilters' Guild operates a regional structure, with local volunteers co-ordinating activities within each region.

List of regions
Region 1: London, Middlesex
Region 2: Kent, Surrey, Sussex
Region 3: Hampshire, Wiltshire, Isle of Wight, Channel Islands
Region 4: Cornwall, Devon, Dorset
Region 5: Bristol, Gloucestershire Somerset
Region 6: Berkshire, Oxfordshire
Region 7: Bedfordshire, Buckinghamshire, Hertfordshire, Northamptonshire
Region 8: Essex, Suffolk
Region 9: Cambridgeshire, Norfolk
Region 10: Derbyshire, Leicestershire, Lincolnshire, Nottinghamshire, Rutland
Region 11: Herefordshire, Worcestershire, Shropshire, Staffordshire, Warwickshire, West Midlands
Region 12: South and Mid Wales
Region 13: Cheshire, Isle of Man, Lancashire, Merseyside, North Wales, Manchester
Region 14: Cleveland and Yorkshire
Region 15E: Durham, Tyne & Wear, Northumberland
Region 15W: Cumbria
Region 16: Scotland
Region 17: Northern Ireland